Mirjam Schönfeld, Isabel Barreto Miranda, Mirjam Schunk, Ibrahim Maduhu, Leonard Maboko, Michael Hoelscher, Nicole Berens-Riha, Andrew Kitua & Thomas Löscher
In Tanzania, drug-resistant malaria parasites are an increasing public health concern. Because of widespread chloroquine (CQ) resistance Tanzania changed its first line treatment recommendations for uncomplicated malaria from CQ to sulfadoxine-pyrimethamine (SP) in 2001. Loss of SP sensitivity is progressing rapidly. SP resistance is associated with mutations in the dihydrofolate reductase (pfdhfr) and dihydropteroate synthase (pfdhps) genes.
Published at: 2007-01-15
Hoelscher, Michaelab; Kim, Bohyeb; Maboko, Leonardc; Mhalu, Fredd; von Sonnenburg, Franka; Birx, Deborah L.e; McCutchan, Francine E.* and the UNAIDS Network for HIV Isolation and Characterization
In Mbeya, a rural region of southwest Tanzania, HIV-1 subtypes A, C and D have been co-circulating since the early 1990s. Objective To define to what extent the co-existence of subtypes has led to recombinant HIV-1 strains and whether there is evidence for epidemic spread of any circulating recombinant form.
Published at: 2001-08-17