Edna O. Viegas ,Arne Kroidl ,Patricia J. Munseri,Marco Missanga,Charlotta Nilsson,Nelson Tembe,Asli Bauer,Agricola Joachim,Sarah Joseph,Philipp Mann,Christof Geldmacher,Sue Fleck,Wolfgang Stöhr,Gabriella Scarlatti,Said Aboud,Muhammad Bakari,Leonard Maboko,Michael Hoelscher,Britta Wahren,Merlin L. Robb,Jonathan Weber,Sheena McCormack,Gunnel Biberfeld,Ilesh V. Jani,Eric Sandström,Eligius Lyamuya,TaMoVac study group
We evaluated the safety and immunogenicity of (i) an intradermal HIV-DNA regimen given with/without intradermal electroporation (EP) as prime and (ii) the impact of boosting with modified vaccinia virus Ankara (HIV-MVA) administered with or without subtype C CN54rgp140 envelope protein adjuvanted with Glucopyranosyl Lipid A (GLA-AF) in volunteers from Tanzania and Mozambique........
Published at: 2018-11-29
Authors: Issa Sabi a 1, Andrea Rachow b c 1, Daniel Mapamba a, Petra Clowes a, Nyanda E. Ntinginya a, Mohamed Sasamalo d, Lujeko Kamwela d, Frederick Haraka d e f, Michael Hoelscher b c, Daniel H. Paris e f, Elmar Saathoff b c, Klaus Reither d e f
We evaluated the diagnostic performance of the novel next-generation Xpert MTB/RIF Ultra (Xpert Ultra) in comparison to Xpert MTB/RIF (Xpert) assay for the detection of paediatric pulmonary tuberculosis in high burden settings.
Published at: 2018-10-04
Mohamed I. M. Ahmed1,2,3, Nyanda E. Ntinginya4, Gibson Kibiki5, Bariki A Mtafya4, Hadija Semvua5, Stellah Mpagama5, Charles Mtabho5, Elmar Saathoff1,2, Kathrin Held1,2, Rebecca Loose1,2, Inge Kroidl1,2, Mkunde Chachage1,4, Ulrich von Both1,2,6, Antelmo Haule4, Anna-Maria Mekota1,2, Martin J. Boeree7, Stephen H. Gillespie8, Michael Hoelscher1,2†, Norbert Heinrich1,2† and Christof Geldmacher1,2* on behalf of the Pan African Consortium for the Evaluation of
The analysis of phenotypic characteristics on Mycobacterium tuberculosis (MTB)-specific T cells is a promising approach for the diagnosis of active tuberculosis (aTB) and for monitoring treatment success. We therefore studied phenotypic changes on MTB-specific CD4 T cells upon anti-tuberculosis treatment initiation in relation to the treatment response as determined by sputum culture.
Published at: 2018-09-28
Donaldson F. Conserve ,Kathryn E. Muessig,Leonard L. Maboko,Sylvia Shirima,Mrema N. Kilonzo,Suzanne Maman,Lusajo Kajula
The purpose of this formative research, guided by the Integrated Behavioral Model, was to assess men’s attitudes and personal agency towards HIV self-testing (HIVST) and confirmatory HIV testing in order to inform the development of the Tanzania STEP (Self-Testing Education and Promotion) Project, a peer-based HIV self-testing intervention for young men in Tanzania. Qualitative in-depth interviews were conducted with 23 men in Dar es Salaam, Tanzania who socialize in networks locally referred to as “camps”. Men reported privacy, confidentiality, and saving time as the primary reasons for their self-testing interest. Most participants had high........
Published at: 2018-08-27
Authors: Issa Sabi, Hellen Mahiga, Jimson Mgaya, Otto Geisenberger, Sabine Kastner, Willyhelmina Olomi, Elmar Saathoff, Lilian Njovu, Cornelia Lueer, John France, Leonard Maboko, Nyanda Elias Ntinginya, Michael Hoelscher, Arne Kroidl
Point-of-care (PoC) systems for early infant diagnosis (EID) may improve timely infant human immunodeficiency virus (HIV) management. Experiences within African public health settings are limited.
Published at: 2018-06-29
Authors: Guenter Froeschl, Elmar Saathoff, Inge Kroidl, Nicole Berens-Riha, Petra Clowes, Leonard Maboko, Weston Assisya, Wolfram Mwalongo, Martina Gerhardt, Elias Nyanda Ntinginya & Michael Hoelscher Malaria Journal
A marked decline in malaria morbidity and mortality has been reported after the introduction of artemisinin-based combination therapy (ACT) in high malaria prevalence countries in Africa. Data on the impact of ACT and on the prevalence of malaria has so far been scarce for Southwest Tanzania.
Published at: 2018-06-26
Authors: Andrea Rachow a b, Elmar Saathoff a b, Bariki Mtafya c, Daniel Mapamba c, Chacha Mangu c, Gabriel Rojas-Ponce c, Nyanda E. Ntinginya c, Martin Boeree d, Norbert Heinrich a, Stephen H. Gillespie e, Michael Hoelscher a b, PanACEA-Consortium
The Xpert MTB/RIF assay detects Mycobacterium tuberculosis in unprocessed or NALC/NaOH- decontaminated sputum. The effect of repeated NALC/NaOH-decontamination on several Xpert performance parameters was assessed in this study. A second NALC/NaOH-decontamination had no effect on the binary Xpert-outcome but increased the value for the quantitative readout (CTmin). Repeated decontamination was not associated with PCR-inhibition or invalid results. The CTmin of M.tb positive samples was ............
Published at: 2018-05-15